Liver Kinase B1
Synonyms: STK11, PJS, “polarization-related protein LKB1”, “Serine/threonine kinase 11”
LKB1 is serine/threonine kinase, which is essential to protect cells from apoptosis in response to agents that elevate intracellular AMP and as such may act as a low-energy checkpoint in the cell1. LKB1 phosphorylates and activates AMPK and PAR12.
LKB1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proceedings of the National Academy of Sciences of the United States of America. 2004 Mar 9;101(10):3329-35.
2. Spicer J, Ashworth A. LKB1 kinase: master and commander of metabolism and polarity. Current Biology. 2004 May 25;14(10):R383-5.