MAP2K5 assay
Mitogen-activated protein kinase kinase 5
Synonyms: HsT17454, MAPKK5, MEK5, PRKMK5
Family: STE
MAP2K5 (MEK5) is a key kinase of the MEK5-ERK5 pathway, which directly phosphorylates and activates several transcription factors including c-Myc, Sap-1, c-Fos, Fra-1, and myocyte enhancer factor family members1. It elicits a variety of biological responses to extracellular signals that include cytokines, growth factors, and various stress stimuli and has been confirmed to play a pivotal role in tumor carcinogenesis and progression.
MAP2K5 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Diao D, Wang L, Wan J, Chen Z, Peng J, Liu H, Chen X, Wang W, Zou L. MEK5 overexpression is associated with the occurrence and development of colorectal cancer. BMC cancer. 2016 Dec;16(1):302.