Mitogen-activated protein kinase kinase kinase kinase 3
Synonyms: GLK, MAPKKKK3, RAB8IPL1
MAP4K3 is a member of Set kinase family and it is known to be activated by UV radiation and the pro-inflammatory cytokine TNF-α1. It is implicated in Jun N-terminal kinase (JNK) and mammalian Target of Rapamycin (mTOR) signalling, as an apoptosis inducer in selective screening for kinase suppressors of the apoptotic intrinsic pathway.
MAP4K3 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Lam D, Dickens D, Reid EB, Loh SH, Moisoi N, Martins LM. MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. Proceedings of the National Academy of Sciences. 2009 Jul 21;106(29):11978-83.