Mitogen-activated protein kinase 1
Synonyms: ERK, ERK2, MAPK2, p41mapk, PRKM1, PRKM2
MAPK1 (ERK2) is a serine/threonine kinase, which is activated by MEK. MAPK1/ERK2 is a part of ERK pathway, which plays a crucial role in multiple cellular processes such as cell proliferation, differentiation, adhesion, migration and survival. ERK pathway is misregulated via germline mutations, causing disease such as type1 neurofibromatosis and Noonan syndrome, and is over-activated in many cancers1.
MAPK1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Pouysségur J, Lenormand P. ERK1 and ERK2 Map kinases: specific roles or functional redundancy?. Frontiers in cell and developmental biology. 2016 Jun 8;4:53.