Mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK2 is a protein kinase and a known substrate of p38 MAP kinase. The p38/MAPK-activated kinase 2 (MK2) pathway is involved in inflammation, cell migration, and cell cycle regulation1. MAPKAPK2 is a promising alternative target to block the p38/MK2 pathway, avoiding the p38 inhibition.
MAPKAPK2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Fiore M, Forli S, Manetti F. Targeting mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2, MK2): medicinal chemistry efforts to lead small molecule inhibitors to clinical trials. Journal of medicinal chemistry. 2015 Nov 9;59(8):3609-34.