Microtubule affinity regulating kinase 3
Synonyms: CTAK1, KP78, PAR-1A
MARK3 is a member of MARK kinase family, which is known to phosphorylate tau protein and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments1. MARK3/CTAK1 is implicated in cell cycle regulation and Ras-signaling through its interactions with two putative substrates, the Cdc25C phosphatase and the MAPK scaffold KSR12.
MARK3 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Timm T, Marx A, Panneerselvam S, Mandelkow E, Mandelkow EM. Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein. BMC neuroscience. 2008 Dec;9(2):S9.
2. Müller J, Ritt DA, Copeland TD, Morrison DK. Functional analysis of C‐TAK1 substrate binding and identification of PKP2 as a new C‐TAK1 substrate. The EMBO Journal. 2003 Sep 1;22(17):4431-42.