AKT serine/threonine kinase 2
AKT kinases play important role in diverse cellular processes including cell proliferation and survival, cell size and response to nutrient availability, tissue invasion and angiogenesis2. AKT2 is the serine/threonine protein kinase, responible for glucose homeostasis1. AKT is one of most frequently hyperactivated kinases in human cancers2. AKT2 upregulation was found in hepatocellular carcinomas and colorectal cancers3,4.
AKT2 assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Gonzalez E, McGraw TE. The Akt kinases: isoform specificity in metabolism and cancer. Cell cycle. 2009 Aug 15;8(16):2502-8.
2. Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene. 2005 Nov 14;24(50):7455-64.
3. Roy HK, Olusola BF, Clemens DL, Karolski WJ, Ratashak A, Lynch HT, et al. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 2002; 23:201-5.
4. Xu X, Sakon M, Nagano H, Hiraoka N, Yamamoto H, Hayashi N, et al. Akt2 expression correlates with prognosis of human hepatocellular carcinoma. Oncol Rep 2004; 11:25-32.