Activin A receptor type 1
Synonyms: ACVR1, ACVR1A, SKR1, ACVRLK2
Family: Tyrosine Kinase-Like (TKL)
ALK2 is a receptor for bone morphogenetic protein (BMP) (1). ALK2 is expressed in many tissues including skeletal muscle and chondrocytes. A mutation in the gene ALK2 is responsible for the fibrodysplasia ossificans progressiva (1).
ALK2 assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nature genetics. 2006 May 1;38(5):525-7.