Activin A receptor type 1B
Synonyms: ActRIB, ALK4, SKR2, ACVRLK4
Family: Tyrosine Kinase-Like (TKL)
ALK4 is the TGF-β type I receptor serine/threonine kinase 1 and among seven ALK members activin A bounds to ALK4 and ALK2 (ActRIB and ActRI) with highest affinity2.
ALK4 assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Byfield SD, Major C, Laping NJ, Roberts AB. SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Molecular pharmacology. 2004 Mar 1;65(3):744-52.
2. Piek E, Moustakas A, Kurisaki A, Heldin CH, ten Dijke P. TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci. 1999 Dec 15;112(24):4557-68.