Bone morphogenetic protein receptor type 1B
Synonyms: BMPR1B, CDw293
Family: Tyrosine Kinase-Like (TKL)
ALK6 is transmembrane serine/threonine kinase receptor, which binds with high affinity to bone morphogenetic proteins (BMPs) 1. The osteoblastic ALK6 is required for osteoblast differentiation and bone formation. ALK6 can be inhibited by dorsomorphin, which selectively inhibits the BMP type I receptors (ALK2, ALK3 and ALK6)2.
ALK6 assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Lin S, Svoboda KK, Feng JQ, Jiang X. The biological function of type I receptors of bone morphogenetic protein in bone. Bone research. 2016;4:16005.
2. Paul BY, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology. 2008 Jan 1;4(1):33-41.