ARG assay
ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms: ABL2, “Abelson-related gene”, ARG, ABLL
Family: TK (Tyrosine kinases)
ARG (Abelson-related gene) is more widely known as ABL2 kinase. As a member of ABL kinase family, it is an essential regulator of the cytoskeleton1. ABL2 kinase can be inhibited by Gleevlec (imatinib, STI571)2.
ARG assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Bradley WD, Koleske AJ. Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts. Journal of cell science. 2009 Oct 1;122(19):3441-54.
2. Procaccia V, Nakayama H, Shimizu A, Klagsbrun M. Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility. Biochemical and biophysical research communications. 2014 May 30;448(2):134-8.