ASK1 assay
Mitogen-activated protein kinase kinase kinase 5
Synonyms: MAP3K5, “apoptosis signal regulating kinase 1”, ASK1, MAPKKK5, MEKK5
Family: STE
ASK1 is a member of ASK family, which is responsible for apoptosis signal-regulating. These are stress-responsive kinases, which can be activated by physicomecial or biological stresses. It is a mitogen-activated protein kinase kinase kinase (MAP3K), which regulates c-Jun N-terminal kinase (JNK) and p381.
ASK1 assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Takeda K, Shimozono R, Noguchi T, Umeda T, Morimoto Y, Naguro I, Tobiume K, Saitoh M, Matsuzawa A, Ichijo H. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. Journal of Biological Chemistry. 2007 Mar 9;282(10):7522-31.