EPH receptor B2
Synonyms: Hek5, Tyro5, DRT, EPHT3, ERK
EPHB2 is a receptor tyrosine kinase, which is one of the EPHB receptors that have a single trans-membrane domain and a short cytoplasmic tail and usually recognize transmembrane ephrin-B ligands1. Binding and activation of Eph-receptor family members requires cell-cell interactions2. EPHB2 was shown to be down regulated in colorectal and up regulated in gastric cancers3.
EPHB2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Husa AM, Magić Ž, Larsson M, Fornander T, Pérez-Tenorio G. EPH/ephrin profile and EPHB2 expression predicts patient survival in breast cancer. Oncotarget. 2016 Apr 19;7(16):21362.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.
3. Xi HQ, Wu XS, Wei B, Chen L. Eph receptors and ephrins as targets for cancer therapy. Journal of cellular and molecular medicine. 2012 Dec 1;16(12):2894-909.