Hematopoietic progenitor kinase 1
Synonyms: “Mitogen-activated protein kinase kinase kinase kinase 1”, MAP4K1
HPK1 is a serine/threonine kinase, which s involved in various cellular events, including mitogen‑activated protein kinase signaling, nuclear factor‑κB signaling, cytokine signaling, cellular proliferation and apoptosis, T-cell receptor/B-cell receptor signaling and T/B/dendritic cell‑mediated immune responses1.
HPK1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Zhang Q, Ding S, Zhang H. Interactions between hematopoietic progenitor kinase 1 and its adaptor proteins. Molecular medicine reports. 2017 Nov 1;16(5):6472-82.
2. Sawasdikosol S, Zha R, Yang B, Burakoff S. HPK1 as a novel target for cancer immunotherapy. Immunologic research. 2012 Dec 1;54(1-3):262-5.