Synonyms: “I-kappa-B kinase”, IkBKA, IKK-alpha, IKK1, IKKA, “inhibitor of nuclear factor kappa-B kinase subunit alpha”, NFKBIKA, TCF16, CHUK, “conserved helix-loop-helix ubiquitous kinase”
IKK-ALPHA is a part of IKK-complex. Together with IKK-BETA, they mediate phosphorylation of IκB proteins and represent a convergence point for most signal transduction pathways leading to NF-κB activation1. IKK-ALPHA functions in the activation of a specific form of NF-κB in response to a subset of TNF family members and may also serve to attenuate IKK-BETA-driven NF-κB activation. IKK-ALPHA is also involved in keratinocyte differentiation, but this function is independent of its kinase activity.
IKK-ALPHA kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Häcker H, Karin M. Regulation and function of IKK and IKK-related kinases. Sci. Stke. 2006 Oct 17;2006(357):re13-.