Microtubule affinity regulating kinase 1
Synonyms: MARK, PAR-1C
MARK1 is a member of MARK kinase family, which is known to phosphorylate tau protein and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments1. MARK1 (and closely related MARK2) phosphorylate microtubule associated proteins (MAPs): MAP2, MAP4 and Tau2.
MARK1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Timm T, Marx A, Panneerselvam S, Mandelkow E, Mandelkow EM. Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein. BMC neuroscience. 2008 Dec;9(2):S9.
2. An overview of the KIN1/PAR-1/MARK kinase family