NUAK family kinase 1
Synonyms: AMP-activated protein kinase family member 5, ARK5, KIAA0537
Family: CAMK ( Ca2+/calmodulin- dependent protein kinase)
NUAK1 is a member of the AMPK-related family of kinases1. Perturbation of NUAK1 has revealed a diverse array of phenotypes, pointing to roles for NUAK1 in regulating cell adhesion, directional migration, neuronal axon branching, glycogen synthesis, replicative senescence and TAU stabilisation. HTH-01-015 was defined to be specific NUAK1 inhibitor2.
NUAK1 assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Monteverde T, Tait-Mulder J, Hedley A, Knight JR, Sansom OJ, Murphy DJ. Calcium signalling links MYC to NUAK1. Oncogene. 2017 Nov 6.
2. Banerjee S, Buhrlage SJ, Huang HT, Deng X, Zhou W, Wang J, Traynor R, Prescott AR, Alessi DR, Gray NS. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochemical Journal. 2014 Jan 1;457(1):215-25.