Technology

Unique Microfluidics platform

Nanosyn mobility shifts assay were developed to measure enzyme activity by monitoring substrate modifications. They are done in vitro and allow performing high-throughput screening and profiling as well as dose-response and kinetic studies. This information can be used further to unravel the mechanism of action and used to drive hit-to-lead optimization.

Precise
Product/Substrate separated
Ratiometric

This platform has a number of benefits:

  • Extremely Precise – Readout allows for very precise determination of enzyme activity based on changes in the product/substrate ratio.
  • Exquisitely Sensitive – Accurately identifies inhibitors not detected by other methods? Not sure, requires small amount of protein, no fluorescence background
  • Rapid Turnaround – Large install base of microfluidic systems provides quicker results. largest in industry park of instruments
  • Sophisticated Informatics – Integration of database and informatics tools for efficient reporting and visualizing of data, customized to your needs.
  • Maximum flexibility – System appropriate for small or large compound sets, one target or a panel of targets.