AURORA-C assay
Aurora kinase C
Synonyms: ARK3, AurC, STK13
Family: Other
Aurora kinases belong to the serine/threonine subclass of kinases and are involved in the regulation of mitosis1. They show increased expression level in a variety of solid and liquid tumours including lung, liver, breast and pancreatic tumors. Aurora C has significant sequence similarity to AURKC, similar structure and small-molecule inhibitor with affinity to AURKB, have affinity to AURKC. However, it was shown that aurora kinase C has some non-overlapping functions with aurora kinase B2.
Aurora kinase C assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Yue Kong, Andreas Bender, and Aixia Yan. Identification of Novel Aurora Kinase A (AURKA) Inhibitors via Hierarchical Ligand-Based Virtual Screening. Journal of Chemical Information and Modeling. DOI: 10.1021/acs.jcim.7b00300
2. Balboula AZ, Schindler K. Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes. PLoS genetics. 2014 Feb 27;10(2):e1004194.