High-throughput screening remains to be the most powerful tool when searching for the initial hits for the new target. Once initial hit is established, screening can be further used in parallel with rational design, substrate or ligand modeling, and fragment screening. Assay employed in HTS has to perform in relevant, reproducible, reliable and robust manner to ensure the quality of HTS results. Our microfluidics platform offers screening and profiling services for 500+ mobility shift assays, including kinases, phosphatases, proteases, PDEs and various epigenetic targets. We offer flexibility in screening and profiling of your compounds: from one compound to whole compound library in variety of formats (single point, two concentration points).
Annotated heat map of Caliper assay screening
We have the industry’s largest number of networked microfluidics instruments. Our screening and profiling services benefit from:
- Low level of false positives and false negatives
- High precision and accuracy of the method allows to run HTS in singlicates
- Strict quality standards
- Capabilities to screen up to 100,000 compounds per day
- Largest portfolio of mobility shift assays run on microfluidics instruments (over 500 different enzyme assays)
- Assay development possiblity
- Targets chosen from important, validated disease pathways
- Library of 400+ peptides allowing for rapid assay development