B-RAF (Rapidly Accelerated Fibrosarcoma) proto-oncogene
Family: TKL (Tyrosine kinase-like)
BRAF is a serine-threonine protein kinase, which is involved in directing cell-growth. RAF kinases participate in MAPK signal transduction cascade. Overexpression or activation of the pathway components commonly contributes to tumor initiation, progression and metastasis1,2.
BRAF kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Leicht DT, Balan V, Kaplun A, Singh-Gupta V, Kaplun L, Dobson M, Tzivion G. Raf kinases: function, regulation and role in human cancer. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2007 Aug 31;1773(8):1196-212.
2. Amaral T, Sinnberg T, Meier F, Krepler C, Levesque M, Niessner H, Garbe C. The mitogen-activated protein kinase pathway in melanoma part I–Activation and primary resistance mechanisms to BRAF inhibition. European Journal of Cancer. 2017 Feb 3.