Brain specific kinase 1
Synonyms: SAD-B, KIAA1811
Family: CAMK (Ca2+/calmodulin- dependent protein kinase)
Brain-specific kinases (BRSK1/2) are AMP-activated protein kinase that are highly expressed in mammalian forebrain1. They play a role in in polarization of neurons and centrosome duplication1,2.
BRSK1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Bright NJ, Carling D, Thornton C. Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation. Journal of Biological Chemistry. 2008 May 30;283(22):14946-54.
2. Kishi M, Pan YA, Crump JG, Sanes JR. Mammalian SAD kinases are required for neuronal polarization. Science. 2005 Feb 11;307(5711):929-32.