CDK5-p35 assay
Cyclin dependent kinase 5 (complex with p35)
Synonyms: cell division protein kinase 5, PSSALRE
Family: CMGC
CDK5 is a proline-directed serine/threonine protein kinase and a member of cyclin dependent kinase family. CDK5 is a a crucial regulator of neuronal migration in the developing central nervous system1. CDK5 shows no enzymatic activity as a monomer, and has two binding partners p35 and p39. The expression of p35 and p39 is the highest in post-mitotic neurons of the nervous system, therefore the primary activity of CDK5 was detected in the nervous system.
CDK5-p35 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Dhavan R, Tsai LH. A decade of CDK5. Nature reviews Molecular cell biology. 2001 Oct 1;2(10):749-59.