CDK9-CYCLIN T1 assay

Cyclin dependent kinase 9 (complex with cyclin T1)

Synonyms: C-2k, PITALRE, TAK, CDC2L4

Family: CMGC

CDK9 is a serine/threonine protein kinase and a member of cyclin dependent kinase family. CDK9 forms active complex with its partner cyclin T comprising the positive transcription elongation factor b (P-TEFb), which promotes transcription elongation1. CDK9 is a promising target for cancer therapy, particularly for cancers driven by transcriptional dysregulation.

CDK9-CYCLIN T1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.


1. Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nature chemical biology. 2017 Dec 18.