CHEK2 assay
Checkpoint kinase 2
Synonyms: bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53
Family: CAMK
CHEK2 is a serine/threonine kinase, which is is activated by ATM in response to DNA damage1. CHEK2 kinase is a stable protein expressed throughout the cell cycle2. CHEK2 has a overlapping functions with CHEK1 kinase and there is an emerging idea of there partnership: CHEK1 operates as a workhorse, while CHEK2 contributes decisively yet only under circumstances that cause double-strand DNA breaks.
CHEK2 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. McGowan CH. Checking in on Cds1 (Chk2): a checkpoint kinase and tumor suppressor. Bioessays. 2002 Jun 1;24(6):502-11.
2. Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer cell. 2003 May 31;3(5):421-9.