CK1-ALPHA1 assay
Casein kinase 1 alpha 1
Synonyms: CK1, CK1a, CK1alpha, CKIa, CKIalpha, “clock regulator kinase”, CSNK1A1
Family: CK1 (Casein Kinase 1)
CK1 kinases isoforms are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation1. CK1α is important for the mitotic spindle formation during cell division and DNA repair mechanisms and participates in RNA metabolism. CK1α, δ and ε were shown to have both positive and negative regulatory function in the Wnt pathway2.
CK1-ALPHA1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Schittek B, Sinnberg T. Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis. Molecular cancer. 2014 Oct 11;13(1):231.
2. Knippschild U, Wolff S, Giamas G, Brockschmidt C, Wittau M, Würl PU, Eismann T, Stöter M. The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Oncology Research and Treatment. 2005;28(10):508-14.