Mitogen-activated protein kinase kinase kinase 8
Synonyms: MAP3K8, c-COT, EST, MEKK8, Tpl-2, ESTF
COT is a mitogen-activated protein kinase kinase kinase (MAP3K) that conveys various intra- and extra-cellular stimuli to effector proteins of cells inducing adequate adoptive responses1. Dysregulation of COT expression and signaling is associated with acute and chronic inflammatory diseases2. COT was shown to be in the control of inflammatory responses and survival in adipocytes, fibroblasts and immune and epithelial cells.
COT kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Lee HW, Choi HY, Joo KM, Nam DH. Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer. International journal of molecular sciences. 2015 Feb 25;16(3):4471-91.
2. Varin EM, Wojtusciszyn A, Broca C, Muller D, Ravier MA, Ceppo F, Renard E, Tanti JF, Dalle S. Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4. Cell death & disease. 2016 Jan 1;7(1):e2065.