Doublecortin like kinase 1
Synonyms: DCDC3A, DCLK, KIAA0369, DCLK1
DCAMKL1 (Doublecortin and CaM kinase-like 1 protein) is a microtubule-associated protein with C-terminal serine/threonine kinase domain1. An over-expression of this protein stimulates microtubule elongation, independent of its kinase function. Although its kinase function is not yet know, the importance of Dclk1 in the developing brain was reported based on its expression in radial glia cells and neuronal precursors2.
DCAMKL1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Westphalen, C. B., Quante, M., & Wang, T. C. Functional implication of Dclk1 and Dclk1-expressing cells in cancer. Small GTPases, 2017, 8(3), 164-171.
2. Walker, T. L., Yasuda, T., Adams, D. J., & Bartlett, P. F. (2007). The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells. Journal of Neuroscience, 27(14), 3734-3742.