EPH receptor A4
Synonyms: Hek8, TYRO1
EPHA4 is a receptor tyrosine kinase that regulates the formation of the corticospinal tract, a pathway controlling voluntary movements, and of the anterior commissure, connecting the neocortical temporal lobes1. Binding and activation of Eph-receptor family members requires cell-cell interactions2.
EPHA4 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Kullander K, Mather NK, Diella F, Dottori M, Boyd AW, Klein R. Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo. Neuron. 2001 Jan 1;29(1):73-84.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.