EPH-B1 assay
EPH receptor B1
Synonyms: Hek6, EPHT2
Family: TK
EPHB1 is a receptor tyrosine kinase that is frequently mutated in cancer1. Binding and activation of Eph-receptor family members requires cell-cell interactions2. EPHB1 is down-regulated in colorectal cancer3.
EPHB1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Mathot L, Kundu S, Ljungström V, Svedlund J, Moens L, Adlerteg T, Falk-Sörqvist E, Rendo V, Bellomo C, Mayrhofer M, Cortina C. Somatic ephrin receptor mutations are associated with metastasis in primary colorectal cancer. Cancer research. 2017 Apr 1;77(7):1730-40.
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature reviews Molecular cell biology. 2002 Jul;3(7):475.
3. Xi HQ, Wu XS, Wei B, Chen L. Eph receptors and ephrins as targets for cancer therapy. Journal of cellular and molecular medicine. 2012 Dec 1;16(12):2894-909.