Homeodomain interacting protein kinase 4
HIPK4 is a member of homeodomain-interacting protein kinase family. HIPKs interact with a vast range of functional proteins, including not only transcriptional regulators and chromatin modifiers, but also cytoplasmic signal transducers, transmembrane proteins, and SUMO ligase1. HIPK4 is a unique member of HIPK family due to its smaller in size and additional distinct features2. HIPK4 lacks a nuclear localization signal and a C-terminal autoinhibitory domain compared to other HIPK proteins.
HIPK4 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Isono K, Nemoto K, Li Y, Takada Y, Suzuki R, Katsuki M, Nakagawara A, Koseki H. Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Molecular and cellular biology. 2006 Apr 1;26(7):2758-71.
2. He Q, Shi J, Sun H, An J, Huang Y, Sheikh MS. Characterization of human homeodomain-interacting protein kinase 4 (HIPK4) as a unique member of the HIPK family. Molecular and cellular pharmacology. 2010;2(2):61.