Inhibitor of nuclear factor kappa B kinase subunit beta
Synonyms: IKK-beta, IKK2, IKKB, NFKBIKB, IKBKB
IKK-BETA is a part of IKK-complex. Together with IKK-BETA, they mediate phosphorylation of IκB proteins and represent a convergence point for most signal transduction pathways leading to NF-κB activation1. IKK-BETA is essential for rapid NF-κB activation by proinflammatory signaling cascades.
IKK-BETA kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Häcker H, Karin M. Regulation and function of IKK and IKK-related kinases. Sci. Stke. 2006 Oct 17;2006(357):re13-.