Interleukin 1 receptor associated kinase 4
IRAK4 is serine/threonine kinase, which is a key protein kinase in immune cells1. It is responsible for initiating MyD88-dependent signaling from most Toll-Like Receptors and Interleukin-1 Receptors, resulting in downstream production of pro-inflammatory cytokines.
IRAK4 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Lamagna C, Chan M, Yi S, Young C, Frances R, Siu S, Braselmann S, Payan DG, McMurtrie D, Kelley R, Heckrodt T. Characterization of a small molecule IRAK4 kinase inhibitor for the treatment of autoimmune and inflammatory diseases.