IRAK4 assay
Interleukin 1 receptor associated kinase 4
Synonyms: NY-REN-64
Family: TKL
IRAK4 is serine/threonine kinase, which is a key protein kinase in immune cells1. It is responsible for initiating MyD88-dependent signaling from most Toll-Like Receptors and Interleukin-1 Receptors, resulting in downstream production of pro-inflammatory cytokines.
IRAK4 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Lamagna C, Chan M, Yi S, Young C, Frances R, Siu S, Braselmann S, Payan DG, McMurtrie D, Kelley R, Heckrodt T. Characterization of a small molecule IRAK4 kinase inhibitor for the treatment of autoimmune and inflammatory diseases.