Leukocyte receptor tyrosine kinase
LTK a receptor tyrosine kinase that has been implicated in autoimmunity, neuronal development, and cancer1. LTK is expressed in pre-B lymphocytes, B lymphocytes, and other hematopoietic cells, as well as brain and placenta, and shares significant homology with anaplastic lymphoma kinase (ALK)2.
LTK kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Zhang H, Pao LI, Zhou A, Brace AD, Halenbeck R, Hsu AW, Bray TL, Hestir K, Bosch E, Lee E, Wang G. Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. Proceedings of the National Academy of Sciences. 2014 Nov 4;111(44):15741-5.
2. Roll JD, Reuther GW. ALK-activating homologous mutations in LTK induce cellular transformation. PLoS One. 2012 Feb 9;7(2):e31733.