Mitogen-activated protein kinase-activated protein kinase 3
Synonyms: 3PK, MAPKAP3, MK3
MAPKAPK3 is a protein kinase, which can bind to p38alpha MAPK and is activated by p38 via multiple proline-directed phosphorylations in a stress-dependent manner1. MAPKAPK3/MK3 is a closely related enzyme to MK2 and can compensate for its loss.
MAPKAPK3 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Ronkina N, Kotlyarov A, Gaestel M. MK2 and MK3–a pair of isoenzymes. Front Biosci. 2008 May 1;13:5511-21.
2. Moens U, Kostenko S, Sveinbjørnsson B. The role of mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) in inflammation. Genes. 2013 Mar 26;4(2):101-33.