Microtubule affinity regulating kinase 4
Synonyms: FLJ90097, KIAA1860, Nbla00650, PAR-1D
MARK4 is a member of MARK kinase family, which is known to phosphorylate tau protein and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments1. MARK4 is associated with the basal body and ciliary axoneme in human and murine cell lines. Overexpression of MARK4 causes thinning out of the microtubule network, concomitant with a reorganization of microtubules into bundles2.
MARK4 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Timm T, Marx A, Panneerselvam S, Mandelkow E, Mandelkow EM. Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein. BMC neuroscience. 2008 Dec;9(2):S9.
2. Trinczek B, Brajenovic M, Ebneth A, Drewes G. MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. Journal of Biological Chemistry. 2004 Feb 13;279(7):5915-23.