ABL assay
ABL proto-oncogene 1, non-receptor tyrosine kinase
Synonyms: c-ABL, JTK7, p150
Family: Tyrosine Kinase (TK)
c-Abl is a non-receptor tyrosine kinase and an indicator of oxidative stress1. Majority of studies are focused on the BCR-ABL oncoprotein and its inhibition2, however it was also shown that ABL has role in Parkinson’s disease1. In the normally functioning cell, ABL has many functional targets from cell signaling adopters to phosphatases. c-Abl functions are implicated in a variety of biological processes including the regulation of cell growth and survival, integrin signaling, actin polymerization and cell migration1.
ABL assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Brahmachari S, Karuppagounder SS, Ge P, Lee S, Dawson VL, Dawson TM, Ko HS. c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential. Journal of Parkinson’s Disease. 2017 Jan 1;7(4):589-601.
2. Wang JY. The capable ABL: what is its biological function?. Molecular and cellular biology. 2014 Apr 1;34(7):1188-97.