AKT serine/threonine kinase 1
Synonyms: AKT, PKB, PRKBA, RAC
AKT kinases play important role in diverse cellular processes including cell proliferation and survival, cell size and response to nutrient availability, tissue invasion and angiogenesis2. AKT1 is the serine/threonine protein kinase, responible for cell growth and angiogenesis1. Akt is one of most frequently hyperactivated kinases in human cancers2. AKT1 upregulation was found in breast cancers3.
AKT1 assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Gonzalez E, McGraw TE. The Akt kinases: isoform specificity in metabolism and cancer. Cell cycle. 2009 Aug 15;8(16):2502-8.
2. Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene. 2005 Nov 14;24(50):7455-64.
3. Stål O, Pérez-Tenorio G, Åkerberg L, Olsson B, Nordenskjöld B, Skoog L, Rutqvist LE. Akt kinases in breast cancer and the results of adjuvant therapy. Breast Cancer Research. 2003 Apr 1;5(2):R37.