AKT3 assay
AKT serine/threonine kinase 3
Synonyms: PKBG, PRKBG, “protein kinase B, gamma”, RAC-gamma
Family: AGC
AKT kinases play important role in diverse cellular processes including cell proliferation and survival, cell size and response to nutrient availability, tissue invasion and angiogenesis2. AKT3 is the serine/threonine protein kinase, responible for neuronal development1. Akt is one of most frequently hyperactivated kinases in human cancers2. AKT3 upregulation was found in estrogen receptor-negative breast tumors3 and melanoma4.
AKT3 assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Gonzalez E, McGraw TE. The Akt kinases: isoform specificity in metabolism and cancer. Cell cycle. 2009 Aug 15;8(16):2502-8.
2. Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene. 2005 Nov 14;24(50):7455-64.
3. Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, Weigel RJ, et al. Upregulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 1999; 274:21528-32.
4. Stahl JM, Sharma A, Cheung M, Zimmerman M, Cheng JQ, Bosenberg MW, et al. Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res 2004; 64:7002-10.