Apoptosis signal regulating kinase 2
Synonyms: mitogen-activated protein kinase kinase kinase 6, apoptosis signal regulating kinase 2, MAPKKK6, MEKK6
ASK2 is serine/threonine kinase highly related to ASK1, which acts in heteromeric complex with ASK11 as functional MAP3K. It was shown that MAP3K6 participates in VEGF expression, and that regulation of VEGF by MAP3K6 may play a crucial role in both angiogenesis and tumorigenesis2.
ASK2 assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Takeda K, Shimozono R, Noguchi T, Umeda T, Morimoto Y, Naguro I, Tobiume K, Saitoh M, Matsuzawa A, Ichijo H. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. Journal of Biological Chemistry. 2007 Mar 9;282(10):7522-31.
2. Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M. Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. The American journal of pathology. 2009 Apr 30;174(4):1553-63.