Ataxia telangiectasia mutated kinase
Synonyms: ATA, ATC, ATD, ATDC, TEL1
ATM is serine/threonine kinase, which is activated in response to DNA double-strand breaks in eukaryotic cells1. ATR and ATM are the most upstream kinases involved in the DNA damage response. However, their DNA-damage specificities are distinct and their functions are not redundant. Both kinases are a members of phosphatidylinositol-3-kinase-like kinase family (PIKKs).
ATM assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
1. Lee JH, Paull TT. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene. 2007 Dec 10;26(56):7741-8.
2. Maréchal, A., & Zou, L. . DNA damage sensing by the ATM and ATR kinases. Cold Spring Harbor perspectives in biology, 2013; 5(9), a012716.