Protease

Nanosyn name Approved name Long name Synonyms Family
BACE1 BACE1 beta-secretase 1 BACE, “beta-site APP-cleaving enzyme 1” aspartyl
CTSD CTSD cathepsin D “ceroid-lipofuscinosis, neuronal 10”, CLN10, CPSD aspartyl
CAPN1 CAPN1 calpain 1 CANP, CANPL1, muCANP, muCL cysteine
CASP1 CASP1 caspase 1 “caspase-1”, ICE, “interleukin 1, beta, convertase”, IL1BC cysteine
CASP2 CASP2 caspase 2 ICH1, MGC2181, PPP1R57, “protein phosphatase 1, regulatory subunit 57”, NEDD2 cysteine
CASP3 CASP3 caspase 3 apopain, CPP32, CPP32B, Yama cysteine
CASP5 CASP5 caspase 5 ICE(rel)III cysteine
CASP6 CASP6 caspase 6 MCH2 cysteine
CASP7 CASP7 caspase 7 CMH-1, ICE-LAP3, MCH3 cysteine
CASP8 CASP8 caspase 8 Casp-8, FLICE, MACH, MCH5 cysteine
CASP9 CASP9 caspase 9 APAF-3, ICE-LAP6, MCH6, PPP1R56, “protein phosphatase 1, regulatory subunit 56” cysteine
CTSB CTSB cathepsin B cysteine
CTSK CTSK cathepsin K PKND, CTSO, CTSO2, PYCD cysteine
CTSL CTSL cathepsin L FLJ31037, CTSL1 cysteine
CTSS CTSS cathepsin S cysteine
FACTOR VII FACTOR VII coagulation factor VII “eptacog alfa”, “factor VII”, “FVII coagulation protein” cysteine
FACTOR Xa FACTOR Xa coagulation factor X cysteine
ACE ACE angiotensin I converting enzyme ACE1, CD143, “peptidyl-dipeptidase A”, DCP1 metallo
ACE2 ACE2 angiotensin I converting enzyme 2 “peptidyl-dipeptidase A” metallo
ADAM10 ADAM10 ADAM metallopeptidase domain 10 CD156c, HsT18717, kuz, MADM metallo
ADAM17 ADAM17 ADAM metallopeptidase domain 17 CD156B, cSVP, TACE metallo
IDE IDE insulin degrading enzyme “insulysin” metallo
MME MME membrane metalloendopeptidase CALLA, CD10, “enkephalinase”, NEP, “neprilysin”, “neutral endopeptidase” metallo
MMP1 MMP1 matrix metallopeptidase 1 CLG, “interstitial collagenase” metallo
MMP12 MMP12 matrix metallopeptidase 12 HME, “macrophage elastase” metallo
MMP13 MMP13 matrix metallopeptidase 13 CLG3, “collagenase 3” metallo
MMP14 MMP14 matrix metallopeptidase 14 “membrane type 1 metalloprotease”, MT1-MMP metallo
MMP2 MMP2 matrix metallopeptidase 2 TBE-1, CLG4, CLG4A metallo
MMP3 MMP3 matrix metallopeptidase 3 STMY, STMY1 metallo
MMP7 MMP7 matrix metallopeptidase 7 “matrilysin”, PUMP-1, MPSL1 metallo
MMP8 MMP8 matrix metallopeptidase 8 CLG1, “matrix metalloproteinase 8 (neutrophil collagenase)” metallo
MMP9 MMP9 matrix metallopeptidase 9 CLG4B, “matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)” metallo
ClpP/X ClpP/X caseinolytic mitochondrial matrix peptidase proteolytic subunit “ATP-dependent protease ClpAP (E. coli), proteolytic subunit, human” serine
DPP3 DPP3 dipeptidyl peptidase 3 “dipeptidylpeptidase III” serine
DPP4 DPP4 dipeptidyl peptidase 4 DPPIV, ADCP2, CD26 serine
DPP8 DPP8 dipeptidyl peptidase 8 “dipeptidyl peptidase IV-related protein-1”, “dipeptidyl peptidase VIII”, DP8, DPRP1, FLJ14920, FLJ20283, MGC26191, MSTP141, “prolyl dipeptidase DPP8” serine
DPP9 DPP9 dipeptidyl peptidase 9 serine
F2 F2 coagulation factor II, thrombin “prepro-coagulation factor II” serine
FAP FAP fibroblast activation protein alpha DPPIV, “seprase” serine
FURIN FURIN furin, paired basic amino acid cleaving enzyme SPC1, FUR, PACE, PCSK3 serine
GZMA GZMA granzyme A “CTL tryptase”, “Cytotoxic T-lymphocyte-associated serine esterase-3”, “granzyme 1”, “Hanukah factor serine protease)”, CTLA3, HFSP serine
GZMB GZMB granzyme B “cathepsin G-like 1”, CCPI, CGL1, CSPB, CTSGL1, “cytotoxic serine protease B”, “cytotoxic T-lymphocyte-associated serine esterase 1”, “fragmentin 2”, “granzyme 2”, HLP, SECT, “T-cell serine protease 1-3E”, CTLA1 serine
GZMK GZMK granzyme K PRSS, TRYP2, “tryptase II” serine
HTRA2 HTRA2 HtrA serine peptidase 2 OMI, PARK13, PRSS25 serine
KLK11 KLK11 kallikrein related peptidase 11 TLSP, PRSS20 serine
KLK13 KLK13 kallikrein related peptidase 13 KLK-L4 serine
KLK3 KLK3 kallikrein related peptidase 3 PSA, APS serine
PLAT PLAT plasminogen activator, tissue type serine
PLAU PLAU plasminogen activator, urokinase UPA, URK serine
PLG PLG plasminogen serine
PREP PREP prolyl endopeptidase “prolyl oligopeptidase” serine
PSMB10, MECL1 PSMB10, MECL1 proteasome subunit beta 10 beta2i, LMP10, MGC1665, MECL1 threonine
PSMB5, beta 5 PSMB5, beta 5 proteasome subunit beta 5 MB1, X threonine
PSMB6, beta 6 PSMB6, beta 6 proteasome subunit beta 6 DELTA, Y threonine
PSMB7, beta 7 PSMB7, beta 7 proteasome subunit beta 7 threonine
PSMB8, LMP7 PSMB8, LMP7 proteasome subunit beta 8 beta5i, D6S216E, PSMB5i, RING10, LMP7 threonine
PSMB9, LMP2 PSMB9, LMP2 proteasome subunit beta 9 beta1i, PSMB6i, RING12, LMP2 threonine
ST14 ST14 suppression of tumorigenicity 14 “epithin”, HAI, “matriptase”, MT-SP1, SNC19, TMPRSS14, PRSS14 serine
TMPRSS5 TMPRSS5 transmembrane protease, serine 5 MGC141886, MGC148044, “spinesin” serine