CRIK assay
Citron rho-interacting serine/threonine kinase
Synonyms: CITK, CRIK, KIAA0949, “serine/threonine kinase 21”, STK21
Family: AGC
CRIK is serine/threonine kinase which is a key component of the midbody and is essential for cytokinesis1. CRIK localizes to the central spindle and midbody. It was shown to be required for chromosome integrity independently of its role in cytokinesis. Inactivation of CRIK kinase causes primary microcephaly in humans and rodents2.
CRIK kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Kawano, Y., Sahin, I., Moschetta, M., Wang, J., Manier, S., Glavey, S., … & Anderson, K. C. (2014). Citron Rho-Interacting Serine/Threonine kinase (CIT) Is a Novel Therapeutic Target in Multiple Myeloma Cells.
2. Bianchi, F. T., Tocco, C., Pallavicini, G., Liu, Y., Vernì, F., Merigliano, C., … & Berto, G. E. (2017). Citron kinase deficiency leads to chromosomal instability and TP53-sensitive microcephaly. Cell Reports, 18(7), 1674-1686.