FLT1 assay
Fms related tyrosine kinase 1
Synonyms: “vascular endothelial growth factor receptor 1”, “vascular permeability factor receptor”, VEGFR1, FLT
Family: TK
FLT1 is a tyrosine kinase and vascular endothelial growth factor receptor, which is classically described as a decoy receptor that does not produce intracellular signals. Recent evidence suggest though that FLT1 promotes cell migration and proliferation through PLCγ and PI3K pathways1. FLT1 (or VEGFR1) acts a predictive biomarker for anti-VEGF efficacy.
FLT1 kinase assay is run on mobility shift microfluidics platform (Caliper), which provides best in industry quality of data. We routinely run services associated with this kinase including: screening, profiling, dose-response studies and kinetic measurements. Please contact us for more information.
References:
1. Weddell JC, Chen S, Imoukhuede PI. VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways. NPJ Systems Biology and Applications. 2017 Dec 19;4(1):1.